› 8pai

X-ray diffraction
1.8Å resolution

Crystal structure of human Histidine Triad Nucleotide-Binding Protein 1 in complex with 5'-O-[N-(3-Indolepropionic acid)sulfamoyl] N2-methyl-2-aminoethenoadenosine

Released:
DOI: 10.2210/pdb8pai/pdb
PDB entry 8pai coloured by chain, front view.
PDB entry 8pai coloured by chain, side view.
PDB entry 8pai coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dolot RM, Dillenburg M, Wagner CR

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156024 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosine 5'-monophosphoramidase HINT1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 126 amino acids
Theoretical weight: 13.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49773 (Residues: 1-126; Coverage: 100%)
Gene names: HINT, HINT1, PKCI1, PRKCNH1
Sequence domains: HIT domain

Ligands and Environments

1 bound ligand:
Ligand XKO 1 x XKO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU PhotonJet-S
Spacegroup: C2
Unit cell:
a: 77.675Å b: 46.434Å c: 63.788Å
α: 90° β: 94.624° γ: 90°
R-values:
R R work R free
0.151 0.149 0.191
Expression system: Escherichia coli BL21(DE3)

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