› 8pau

X-ray diffraction
2.8Å resolution

Crystal structure of MAP4K1 with a SMOL inhibitor

Released:
DOI: 10.2210/pdb8pau/pdb
PDB entry 8pau coloured by chain, front view.
PDB entry 8pau coloured by chain, side view.
PDB entry 8pau coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Friberg A

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187813 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase kinase kinase kinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 288 amino acids
Theoretical weight: 32.31 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q92918 (Residues: 7-294; Coverage: 35%)
Gene names: HPK1, MAP4K1
Sequence domains: Protein kinase domain

Ligands and Environments

1 bound ligand:
Ligand XOR 2 x XOR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 60.983Å b: 99.904Å c: 61.101Å
α: 90° β: 101.94° γ: 90°
R-values:
R R work R free
0.219 0.217 0.272
Expression system: Spodoptera frugiperda

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