› 8pdd

X-ray diffraction
1.25Å resolution

Function and Biology Details

Reaction catalysed: 
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188301 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
thioredoxin-disulfide reductase Chains: A, B
Molecule details ›
Chains: A, B
Length: 597 amino acids
Theoretical weight: 64.92 KDa
Source organism: Schistosoma mansoni
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q962Y6 (Residues: 2-596; Coverage: 100%)
Gene name: TGR
Sequence domains:

Ligands and Environments


Cofactor: Ligand FAD 2 x FAD
2 bound ligands:
Ligand MG 3 x MG
Ligand GOL 15 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 61.9Å b: 102.4Å c: 131.46Å
α: 90° β: 92.39° γ: 90°
R-values:
R R work R free
0.144 0.143 0.163
Expression system: Spodoptera frugiperda

Quick links

Citations

1 mention without citation

Fragment library screening by X-ray crystallography and binding site analysis on thioredoxin glutathione reductase of Schistosoma mansoni.
de Souza Neto et al. (2024)