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Zika Methyltransferase in complex with AT-9010 and SAH

X-ray diffraction
2Å resolution
PDB entry 8pem coloured by chain, front view.
PDB entry 8pem coloured by chain, side view.
PDB entry 8pem coloured by chain, top view.
Source organism: Zika virus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine protease subunit NS2B
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Multimeric state: monomeric
Accessible surface area: 11659.02 Å2
Buried surface area: 309.47 Å2
Dissociation area: 50.81 Å2
Dissociation energy (ΔGdiss): 10.66 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-174291

Macromolecules

RNA-directed RNA polymerase NS5
Chain: A
Length: 264 amino acids
Theoretical weight: 29.32 KDa
Source organism: Zika virus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q32ZE1 (Residues: 2517-2780; Coverage: 8%)
Pfam: FtsJ-like methyltransferase
RNA-directed RNA polymerase NS5 in PDB entry 8pem, assembly 1, front view.
RNA-directed RNA polymerase NS5 in PDB entry 8pem, assembly 1, side view.
RNA-directed RNA polymerase NS5 in PDB entry 8pem, assembly 1, top view.
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