› 8pg0

Electron Microscopy
2.97Å resolution

Human OATP1B3

Released:
DOI: 10.2210/pdb8pg0/pdb
PDB entry 8pg0 coloured by chain, front view.
PDB entry 8pg0 coloured by chain, side view.
PDB entry 8pg0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human drug transporters OATP1B1 and OATP1B3.
Ciută AD, Nosol K, Kowal J, Mukherjee S, Ramírez AS, Stieger B, Kossiakoff AA, Locher KP
OpenAccess logo Nat Commun 14 5774 (2023)
PMID: 37723174
Related structures: EMD-17655

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-230398 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Solute carrier organic anion transporter family member 1B3 Chain: A
Molecule details ›
Chain: A
Length: 702 amino acids
Theoretical weight: 77.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Fab19 (heavy chain, variable region) Chain: H
Molecule details ›
Chain: H
Length: 240 amino acids
Theoretical weight: 25.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Fab19 (light chain, variable region) Chain: L
Molecule details ›
Chain: L
Length: 215 amino acids
Theoretical weight: 23.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

3 bound ligands:
Ligand NAG 1 x NAG
Ligand BCT 1 x BCT
Ligand CLR 3 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.97Å
Relevant EMDB volumes: EMD-17655
Expression systems:
  • Homo sapiens
  • Escherichia coli

Quick links

Citations

2 review citations

Membrane transporters in drug development and as determinants of precision medicine.
Galetin et al. (2024)
1 more

1 mention without citation

Structure of human drug transporters OATP1B1 and OATP1B3.
Ciută et al. (2023)