› 8phw

Electron Microscopy
3.6Å resolution

Human OATP1B1

Released:
DOI: 10.2210/pdb8phw/pdb
PDB entry 8phw coloured by chain, front view.
PDB entry 8phw coloured by chain, side view.
PDB entry 8phw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human drug transporters OATP1B1 and OATP1B3.
Ciută AD, Nosol K, Kowal J, Mukherjee S, Ramírez AS, Stieger B, Kossiakoff AA, Locher KP
Nat Commun 14 5774 (2023)
PMID: 37723174
Related structures: EMD-17677

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-230405 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Solute carrier organic anion transporter family member 1B1 Chain: A
Molecule details ›
Chain: A
Length: 691 amino acids
Theoretical weight: 76.52 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9Y6L6 (Residues: 1-691; Coverage: 100%)
Gene names: LST1, OATP1B1, OATP2, OATPC, SLC21A6, SLCO1B1
Sequence domains:
Fab18 (heavy chain, variable region) Chain: H
Molecule details ›
Chain: H
Length: 230 amino acids
Theoretical weight: 24.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Fab18 (light chain, variable region) Chain: L
Molecule details ›
Chain: L
Length: 215 amino acids
Theoretical weight: 23.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

2 bound ligands:
Ligand FY5 1 x FY5
Ligand Y01 1 x Y01
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-17677
Expression systems:
  • Homo sapiens
  • Escherichia coli

Quick links

Citations

2 review citations

Blood-brain barrier transporters: a translational consideration for CNS delivery of neurotherapeutics.
Ronaldson et al. (2024)
1 more

1 mention without citation

Structure of human drug transporters OATP1B1 and OATP1B3.
Ciută et al. (2023)