PDB 8pj1 structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Reactions catalysed:

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate

GTP + H(2)O = GDP + phosphate

Biochemical function:

protein binding

Biological process:

translation

Cellular component:

cytoplasm

Sequence domains:

Structure analysis Details

Assembly composition:

hetero 54-mer (preferred)

PDBe Complex ID:

PDB-CPX-249646 (preferred)

Entry contents:

51 distinct polypeptide molecules
3 distinct RNA molecules

Macromolecules (54 distinct):

Eukaryotic translation initiation factor 3 subunit B Chain: 1

Molecule details ›

Chain: 1
Length: 814 amino acids
Theoretical weight: 92.59 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P55884 (Residues: 1-814; Coverage: 100%)

Gene names: EIF3B, EIF3S9
Sequence domains:

Eukaryotic translation initiation factor 3 subunit I Chain: 2

Molecule details ›

Chain: 2
Length: 325 amino acids
Theoretical weight: 36.54 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q13347 (Residues: 1-325; Coverage: 100%)

Gene names: EIF3I, EIF3S2, TRIP1
Sequence domains:

Eukaryotic translation initiation factor 3 subunit K Chain: 3

Molecule details ›

Chain: 3
Length: 218 amino acids
Theoretical weight: 25.08 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q9UBQ5 (Residues: 1-218; Coverage: 100%)

Gene names: ARG134, EIF3K, EIF3S12, HSPC029, MSTP001, PTD001
Sequence domains: CSN8/PSMD8/EIF3K family

Eukaryotic translation initiation factor 3 subunit F Chain: 4

Molecule details ›

Chain: 4
Length: 357 amino acids
Theoretical weight: 37.59 KDa
Source organism: Homo sapiens
UniProt:

Canonical: O00303 (Residues: 1-357; Coverage: 100%)

Gene names: EIF3F, EIF3S5
Sequence domains:

Eukaryotic translation initiation factor 3 subunit L Chain: 5

Molecule details ›

Chain: 5
Length: 564 amino acids
Theoretical weight: 66.8 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q9Y262 (Residues: 1-564; Coverage: 100%)

Gene names: EIF3EIP, EIF3L, EIF3S6IP, HSPC021, HSPC025, MSTP005
Sequence domains: RNA polymerase I-associated factor PAF67

Eukaryotic translation initiation factor 3 subunit M Chain: 6

Molecule details ›

Chain: 6
Length: 374 amino acids
Theoretical weight: 42.56 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q7L2H7 (Residues: 1-374; Coverage: 100%)

Gene names: EIF3M, GA17, HFLB5, PCID1, PNAS-125
Sequence domains:

Eukaryotic translation initiation factor 3 subunit H Chain: 8

Molecule details ›

Chain: 8
Length: 352 amino acids
Theoretical weight: 39.98 KDa
Source organism: Homo sapiens
UniProt:

Canonical: O15372 (Residues: 1-352; Coverage: 100%)

Gene names: EIF3H, EIF3S3
Sequence domains:

Small ribosomal subunit protein eS32 Chain: 9

Molecule details ›

Chain: 9
Length: 25 amino acids
Theoretical weight: 3.47 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62945 (Residues: 1-25; Coverage: 100%)

Gene name: RPL41
Sequence domains: Ribosomal protein L41

Small ribosomal subunit protein uS17 Chain: B

Molecule details ›

Chain: B
Length: 158 amino acids
Theoretical weight: 18.47 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62280 (Residues: 1-158; Coverage: 100%)

Gene name: RPS11
Sequence domains:

Small ribosomal subunit protein eS4, X isoform Chain: C

Molecule details ›

Chain: C
Length: 263 amino acids
Theoretical weight: 29.65 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62701 (Residues: 1-263; Coverage: 100%)

Gene names: CCG2, RPS4, RPS4X, SCAR
Sequence domains:

Small ribosomal subunit protein uS4 Chain: D

Molecule details ›

Chain: D
Length: 194 amino acids
Theoretical weight: 22.64 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P46781 (Residues: 1-194; Coverage: 100%)

Gene name: RPS9
Sequence domains:

Small ribosomal subunit protein uS12 Chain: E

Molecule details ›

Chain: E
Length: 143 amino acids
Theoretical weight: 15.84 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62266 (Residues: 1-143; Coverage: 100%)

Gene name: RPS23
Sequence domains: Ribosomal protein S12/S23

Small ribosomal subunit protein eS30 Chain: F

Molecule details ›

Chain: F
Length: 59 amino acids
Theoretical weight: 6.67 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62861 (Residues: 75-133; Coverage: 44%)

Gene name: FAU
Sequence domains: Ribosomal protein S30

Small ribosomal subunit protein eS7 Chain: G

Molecule details ›

Chain: G
Length: 194 amino acids
Theoretical weight: 22.17 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62081 (Residues: 1-194; Coverage: 100%)

Gene name: RPS7
Sequence domains: Ribosomal protein S7e

Small ribosomal subunit protein eS27 Chain: H

Molecule details ›

Chain: H
Length: 84 amino acids
Theoretical weight: 9.48 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P42677 (Residues: 1-84; Coverage: 100%)

Gene names: MPS1, RPS27
Sequence domains: Ribosomal protein S27

Small ribosomal subunit protein uS15 Chain: I

Molecule details ›

Chain: I
Length: 151 amino acids
Theoretical weight: 17.26 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62277 (Residues: 1-151; Coverage: 100%)

Gene name: RPS13
Sequence domains:

Small ribosomal subunit protein uS8 Chain: J

Molecule details ›

Chain: J
Length: 130 amino acids
Theoretical weight: 14.87 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62244 (Residues: 1-130; Coverage: 100%)

Gene names: OK/SW-cl.82, RPS15A
Sequence domains: Ribosomal protein S8

Small ribosomal subunit protein eS21 Chain: K

Molecule details ›

Chain: K
Length: 83 amino acids
Theoretical weight: 9.12 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P63220 (Residues: 1-83; Coverage: 100%)

Gene name: RPS21
Sequence domains: Ribosomal protein S21e

Small ribosomal subunit protein uS5 Chain: L

Molecule details ›

Chain: L
Length: 293 amino acids
Theoretical weight: 31.38 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P15880 (Residues: 1-293; Coverage: 100%)

Gene names: RPS2, RPS4
Sequence domains:

Small ribosomal subunit protein eS17 Chain: M

Molecule details ›

Chain: M
Length: 135 amino acids
Theoretical weight: 15.58 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P08708 (Residues: 1-135; Coverage: 100%)

Gene names: RPS17, RPS17L
Sequence domains: Ribosomal S17

Small ribosomal subunit protein uS2 Chain: N

Molecule details ›

Chain: N
Length: 295 amino acids
Theoretical weight: 32.88 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P08865 (Residues: 1-295; Coverage: 100%)

Gene names: LAMBR, LAMR1, RPSA
Sequence domains:

Small ribosomal subunit protein eS1 Chain: O

Molecule details ›

Chain: O
Length: 264 amino acids
Theoretical weight: 30 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P61247 (Residues: 1-264; Coverage: 100%)

Gene names: FTE1, MFTL, RPS3A
Sequence domains: Ribosomal S3Ae family

Small ribosomal subunit protein uS11 Chain: P

Molecule details ›

Chain: P
Length: 151 amino acids
Theoretical weight: 16.3 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62263 (Residues: 1-151; Coverage: 100%)

Gene names: PRO2640, RPS14
Sequence domains: Ribosomal protein S11

Small ribosomal subunit protein eS26 Chain: Q

Molecule details ›

Chain: Q
Length: 115 amino acids
Theoretical weight: 13.05 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62854 (Residues: 1-115; Coverage: 100%)

Gene name: RPS26
Sequence domains: Ribosomal protein S26e

Small ribosomal subunit protein eS8 Chain: R

Molecule details ›

Chain: R
Length: 208 amino acids
Theoretical weight: 24.26 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62241 (Residues: 1-208; Coverage: 100%)

Gene names: OK/SW-cl.83, RPS8
Sequence domains: Ribosomal protein S8e

Small ribosomal subunit protein eS6 Chain: S

Molecule details ›

Chain: S
Length: 249 amino acids
Theoretical weight: 28.75 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62753 (Residues: 1-249; Coverage: 100%)

Gene names: OK/SW-cl.2, RPS6
Sequence domains: Ribosomal protein S6e

Small ribosomal subunit protein eS24 Chain: T

Molecule details ›

Chain: T
Length: 133 amino acids
Theoretical weight: 15.46 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62847 (Residues: 1-133; Coverage: 100%)

Gene name: RPS24
Sequence domains: Ribosomal protein S24e

Small ribosomal subunit protein uS7 Chain: V

Molecule details ›

Chain: V
Length: 204 amino acids
Theoretical weight: 22.91 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P46782 (Residues: 1-204; Coverage: 100%)

Gene name: RPS5
Sequence domains: Ribosomal protein S7p/S5e

Small ribosomal subunit protein uS9 Chain: Y

Molecule details ›

Chain: Y
Length: 146 amino acids
Theoretical weight: 16.48 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62249 (Residues: 1-146; Coverage: 100%)

Gene name: RPS16
Sequence domains: Ribosomal protein S9/S16

Small ribosomal subunit protein uS3 Chain: Z

Molecule details ›

Chain: Z
Length: 243 amino acids
Theoretical weight: 26.73 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P23396 (Residues: 1-243; Coverage: 100%)

Gene names: OK/SW-cl.26, RPS3
Sequence domains:

Small ribosomal subunit protein eS10 Chain: a

Molecule details ›

Chain: a
Length: 165 amino acids
Theoretical weight: 18.93 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P46783 (Residues: 1-165; Coverage: 100%)

Gene name: RPS10
Sequence domains: Plectin/S10 domain

Small ribosomal subunit protein uS19 Chain: b

Molecule details ›

Chain: b
Length: 145 amino acids
Theoretical weight: 17.08 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62841 (Residues: 1-145; Coverage: 100%)

Gene names: RIG, RPS15
Sequence domains: Ribosomal protein S19

Small ribosomal subunit protein RACK1 Chain: c

Molecule details ›

Chain: c
Length: 317 amino acids
Theoretical weight: 35.12 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P63244 (Residues: 1-317; Coverage: 100%)

Gene names: GNB2L1, HLC7, PIG21, RACK1
Sequence domains: WD domain, G-beta repeat

Small ribosomal subunit protein eS19 Chain: d

Molecule details ›

Chain: d
Length: 145 amino acids
Theoretical weight: 16.09 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P39019 (Residues: 1-145; Coverage: 100%)

Gene name: RPS19
Sequence domains: Ribosomal protein S19e

Small ribosomal subunit protein eS25 Chain: e

Molecule details ›

Chain: e
Length: 125 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62851 (Residues: 1-125; Coverage: 100%)

Gene name: RPS25
Sequence domains: S25 ribosomal protein

Small ribosomal subunit protein uS13 Chain: f

Molecule details ›

Chain: f
Length: 152 amino acids
Theoretical weight: 17.76 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62269 (Residues: 1-152; Coverage: 100%)

Gene names: D6S218E, RPS18
Sequence domains: Ribosomal protein S13/S18

Small ribosomal subunit protein uS10 Chain: h

Molecule details ›

Chain: h
Length: 119 amino acids
Theoretical weight: 13.4 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P60866 (Residues: 1-119; Coverage: 100%)

Gene name: RPS20
Sequence domains: Ribosomal protein S10p/S20e

Small ribosomal subunit protein uS14 Chain: i

Molecule details ›

Chain: i
Length: 56 amino acids
Theoretical weight: 6.69 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62273 (Residues: 1-56; Coverage: 100%)

Gene name: RPS29
Sequence domains: Ribosomal protein S14p/S29e

Ubiquitin-ribosomal protein eS31 fusion protein Chain: k

Molecule details ›

Chain: k
Length: 157 amino acids
Theoretical weight: 18.08 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62979 (Residues: 1-87, 88-156; Coverage: 100%)

Gene names: RPS27A, UBA80, UBCEP1
Sequence domains:

Small ribosomal subunit protein eS12 Chain: m

Molecule details ›

Chain: m
Length: 132 amino acids
Theoretical weight: 14.54 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P25398 (Residues: 1-132; Coverage: 100%)

Gene name: RPS12
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

Small ribosomal subunit protein eS28 Chain: n

Molecule details ›

Chain: n
Length: 69 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62857 (Residues: 1-69; Coverage: 100%)

Gene name: RPS28
Sequence domains: Ribosomal protein S28e

Eukaryotic translation initiation factor 3 subunit G Chain: o

Molecule details ›

Chain: o
Length: 320 amino acids
Theoretical weight: 35.66 KDa
Source organism: Homo sapiens
UniProt:

Canonical: O75821 (Residues: 1-320; Coverage: 100%)

Gene names: EIF3G, EIF3S4
Sequence domains:

Eukaryotic translation initiation factor 1 Chain: p

Molecule details ›

Chain: p
Length: 113 amino acids
Theoretical weight: 12.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:

Canonical: P41567 (Residues: 1-113; Coverage: 100%)

Gene names: EIF1, SUI1
Sequence domains: Translation initiation factor SUI1

Eukaryotic translation initiation factor 1A, X-chromosomal Chain: q

Molecule details ›

Chain: q
Length: 144 amino acids
Theoretical weight: 16.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt: