Function and Biology Details
Reactions catalysed:
(1a) L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-272545 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Cysteine desulfurase
Molecule details ›
Chain: A
Length: 404 amino acids
Theoretical weight: 44.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Aminotransferase class-V
Length: 404 amino acids
Theoretical weight: 44.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q9Y697 (Residues: 56-457; Coverage: 88%)
Sequence domains: Aminotransferase class-V
LYR motif-containing protein 4
Molecule details ›
Chain: B
Length: 115 amino acids
Theoretical weight: 13.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Complex 1 protein (LYR family)
Length: 115 amino acids
Theoretical weight: 13.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: Q9HD34 (Residues: 1-91; Coverage: 100%)
Sequence domains: Complex 1 protein (LYR family)
Acyl carrier protein
Iron-sulfur cluster assembly enzyme ISCU
Extramitochondrial frataxin
