› 8pkg

Electron Microscopy
2.99Å resolution

ATTRV122I amyloid fibril from hereditary ATTR amloidosis

Released:
DOI: 10.2210/pdb8pkg/pdb
PDB entry 8pkg coloured by chain, front view.
PDB entry 8pkg coloured by chain, side view.
PDB entry 8pkg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Common transthyretin-derived amyloid fibril structures in patients with hereditary ATTR amyloidosis.
Steinebrei M, Baur J, Pradhan A, Kupfer N, Wiese S, Hegenbart U, Schönland SO, Schmidt M, Fändrich M
OpenAccess logo Nat Commun 14 7623 (2023)
PMID: 37993462
Related structures: EMD-17738

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-236261 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 127 amino acids
Theoretical weight: 13.79 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.99Å
Relevant EMDB volumes: EMD-17738

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