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Thioredoxin glutathione reductase of Schistosoma mansoni fragment screen hit 6.

Source organism: Schistosoma mansoni
Biochemical function: flavin adenine dinucleotide binding
Biological process: cellular oxidant detoxification
Cellular component: cytosol

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EC 1.8.1.9: Thioredoxin-disulfide reductase

Reaction catalysed:
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH
Systematic name:
Thioredoxin:NADP(+) oxidoreductase
Alternative Name(s):
  • NADP--thioredoxin reductase
  • NADPH(2):oxidized thioredoxin oxidoreductase
  • NADPH--thioredoxin reductase
  • NADPH:oxidized thioredoxin oxidoreductase
  • Thioredoxin reductase (NADPH)

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02852
Domain description: Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
Occurring in:
  1. thioredoxin-disulfide reductase
The deposited structure of PDB entry 8pl5 contains 2 copies of Pfam domain PF02852 (Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain) in thioredoxin-disulfide reductase. Showing 1 copy in chain A.

PF07992
Domain description: Pyridine nucleotide-disulphide oxidoreductase
Occurring in:
  1. thioredoxin-disulfide reductase
The deposited structure of PDB entry 8pl5 contains 2 copies of Pfam domain PF07992 (Pyridine nucleotide-disulphide oxidoreductase) in thioredoxin-disulfide reductase. Showing 1 copy in chain A.

PF00462
Domain description: Glutaredoxin
Occurring in:
  1. thioredoxin-disulfide reductase
The deposited structure of PDB entry 8pl5 contains 2 copies of Pfam domain PF00462 (Glutaredoxin) in thioredoxin-disulfide reductase. Showing 1 copy in chain A.

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