› 8pls

X-ray diffraction
1.8Å resolution

Function and Biology Details

Reaction catalysed: 
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188301 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
thioredoxin-disulfide reductase Chains: A, B
Molecule details ›
Chains: A, B
Length: 597 amino acids
Theoretical weight: 64.92 KDa
Source organism: Schistosoma mansoni
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q962Y6 (Residues: 2-596; Coverage: 100%)
Gene name: TGR
Sequence domains:

Ligands and Environments


Cofactor: Ligand FAD 2 x FAD
1 bound ligand:
Ligand B0M 2 x B0M
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P21
Unit cell:
a: 62.242Å b: 103.71Å c: 134.47Å
α: 90° β: 91.84° γ: 90°
R-values:
R R work R free
0.192 0.191 0.216
Expression system: Spodoptera frugiperda

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