› 8pt8

X-ray diffraction
2.78Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155379 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 8 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 366 amino acids
Theoretical weight: 42.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P45983 (Residues: 1-364; Coverage: 85%)
  • Best match: P45983-3 (Residues: 1-364)
Gene names: JNK1, MAPK8, PRKM8, SAPK1, SAPK1C
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
Ligand A3O 3 x A3O
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)
Spacegroup: P31
Unit cell:
a: 107.72Å b: 107.72Å c: 99.085Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.219 0.206 0.218
Expression system: Escherichia coli BL21(DE3)

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