8ptz

Electron Microscopy
3.35Å resolution

Cryo-EM structure of human Elp123 in complex with tRNA, S-ethyl-CoA, 5'-deoxyadenosine and methionine

Released:

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-243106 (preferred)
Entry contents:
3 distinct polypeptide molecules
1 distinct RNA molecule
Macromolecules (4 distinct):
Elongator complex protein 1 Chain: A
Molecule details ›
Chain: A
Length: 1332 amino acids
Theoretical weight: 150.43 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O95163 (Residues: 1-1332; Coverage: 100%)
Gene names: ELP1, IKAP, IKBKAP
Sequence domains: IKI3 family
Elongator complex protein 2 Chain: B
Molecule details ›
Chain: B
Length: 826 amino acids
Theoretical weight: 92.6 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q6IA86 (Residues: 1-826; Coverage: 100%)
Gene names: ELP2, STATIP1
Sequence domains: WD domain, G-beta repeat
Elongator complex protein 3 Chain: C
Molecule details ›
Chain: C
Length: 581 amino acids
Theoretical weight: 65.74 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9H9T3 (Residues: 1-547; Coverage: 100%)
Gene name: ELP3
Sequence domains:
tRNA Gln Chain: X
Molecule details ›
Chain: X
Length: 75 nucleotides
Theoretical weight: 24.05 KDa
Sequence domains: tRNA

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.35Å
Relevant EMDB volumes: EMD-17926
Expression system: Spodoptera frugiperda