8pwh

Electron Microscopy
3.17Å resolution

Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-240206 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (6 distinct):
Trastuzumab Fab light chain Chain: A
Molecule details ›
Chain: A
Length: 214 amino acids
Theoretical weight: 23.47 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Trastuzumab Fab heavy chain Chain: B
Molecule details ›
Chain: B
Length: 220 amino acids
Theoretical weight: 23.43 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Pertuzumab Fab light chain Chain: C
Pertuzumab Fab heavy chain Chain: D
Receptor tyrosine-protein kinase erbB-2 Chain: E

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.17Å
Relevant EMDB volumes: EMD-17993
Expression systems:
  • Cricetulus griseus
  • Homo sapiens