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Isopenicillin N synthase in complex with Fe, O2, ACdV or thioaldehyde after 4s O2 exposure

Source organism: Aspergillus nidulans FGSC A4
Biochemical function: metal ion binding
Biological process: small molecule biosynthetic process
Cellular component: cytosol

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EC 1.21.3.1: Isopenicillin-N synthase

Reaction catalysed:
N-((5S)-5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + O(2) = isopenicillin N + 2 H(2)O
Systematic name:
N-((5S)-5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing)
Alternative Name(s):
  • Isopenicillin N synthase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF03171
Domain description: 2OG-Fe(II) oxygenase superfamily
Occurring in:
  1. Isopenicillin N synthase
The deposited structure of PDB entry 8pya contains 1 copy of Pfam domain PF03171 (2OG-Fe(II) oxygenase superfamily) in Isopenicillin N synthase. Showing 1 copy in chain A.

PF14226
Domain description: non-haem dioxygenase in morphine synthesis N-terminal
Occurring in:
  1. Isopenicillin N synthase
The deposited structure of PDB entry 8pya contains 1 copy of Pfam domain PF14226 (non-haem dioxygenase in morphine synthesis N-terminal) in Isopenicillin N synthase. Showing 1 copy in chain A.

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