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Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation

Source organism: Homo sapiens
Biochemical function: catalytic activity
Biological process: not assigned
Cellular component: not assigned

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EC 3.1.16.1: Spleen exonuclease

Reaction catalysed:
Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 3'-phosphates
Systematic name:
-
Alternative Name(s):
  • 3'-exonuclease
  • 3'-nucleotide phosphodiesterase
  • Phosphodiesterase II
  • Spleen phosphodiesterase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF13918
Domain description: PLD-like domain
Occurring in:
  1. 5'-3' exonuclease PLD3
The deposited structure of PDB entry 8q1k contains 2 copies of Pfam domain PF13918 (PLD-like domain) in 5'-3' exonuclease PLD3. Showing 1 copy in chain A.

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