PDB 8q39 citation summary ‹ Protein Data Bank in Europe (PDBe)

Structure-Based Design of a Potent and Selective YTHDC1 Ligand.

Zálešák F, Nai F, Herok M, Bochenkova E, Bedi RK, Li Y, Errani F, Caflisch A

J Med Chem (2024)

Related entries: 8q2q, 8q2r, 8q2s, 8q2t, 8q2u, 8q2v, 8q2w, 8q2x, 8q2y, 8q31, 8q32, 8q33, 8q35, 8q37, 8q38, 8q3a, 8q3g, 8q4m, 8q4n, 8q4p, 8q4q, 8q4r, 8q4t, 8q4u, 8q4v, 8q4w

PMID: 38787793

10.1021/acs.jmedchem.4c00599

Abstract

N₆-Adenosine methylation (m₆A) is a prevalent post-transcriptional modification of mRNA, with YTHDC1 being the reader protein responsible for recognizing this modification in the cell nucleus. Here, we present a protein structure-based medicinal chemistry campaign that resulted in the YTHDC1 inhibitor

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8q39 › Citations

Structure-Based Design of a Potent and Selective YTHDC1 Ligand.

Abstract

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