› 8q4g

Electron Microscopy
8Å resolution

Thin filament from FIB milled relaxed left ventricular mouse myofibrils

Released:
DOI: 10.2210/pdb8q4g/pdb
PDB entry 8q4g coloured by chain, front view.
PDB entry 8q4g coloured by chain, side view.
PDB entry 8q4g coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure of the native myosin filament in the relaxed cardiac sarcomere.
Tamborrini D, Wang Z, Wagner T, Tacke S, Stabrin M, Grange M, Kho AL, Rees M, Bennett P, Gautel M, Raunser S
Nature (2023)
PMID: 37914933
Related structures: EMD-18147

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-234038 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Actin, alpha cardiac muscle 1 Chains: A, B, C, D, E, F, I
Molecule details ›
Chains: A, B, C, D, E, F, I
Length: 372 amino acids
Theoretical weight: 41.47 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P68033 (Residues: 6-377; Coverage: 99%)
Gene names: Actc, Actc1
Sequence domains: Actin
Tropomyosin alpha-1 chain Chains: G, H
Molecule details ›
Chains: G, H
Length: 179 amino acids
Theoretical weight: 20.84 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P58771 (Residues: 92-270; Coverage: 63%)
Gene names: Tpm-1, Tpm1, Tpma
Sequence domains: Tropomyosin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 8Å
Relevant EMDB volumes: EMD-18147

Quick links

Citations

3 citation in other articles

Getting to the heart of thick-filament structure.
Knight PJ. (2023)
2 more