› 8q5r

X-ray diffraction
2.1Å resolution

HpARI bound to mouse IL-33

Released:
DOI: 10.2210/pdb8q5r/pdb
PDB entry 8q5r coloured by chain, front view.
PDB entry 8q5r coloured by chain, side view.
PDB entry 8q5r coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for IL-33 recognition and its antagonism by the helminth effector protein HpARI2.
Jamwal A, Colomb F, McSorley HJ, Higgins MK
OpenAccess logo Nat Commun 15 5226 (2024)
PMID: 38890291

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-275699 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interleukin-33(109-266) Chain: A
Molecule details ›
Chain: A
Length: 158 amino acids
Theoretical weight: 17.57 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8BVZ5 (Residues: 109-266; Coverage: 59%)
Gene name: Il33
Sequence domains: Interleukin 33
Alarmin release inhibitor Chain: B
Molecule details ›
Chain: B
Length: 237 amino acids
Theoretical weight: 25.88 KDa
Source organism: Heligmosomoides bakeri
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A3P7XL18 (Residues: 63-297; Coverage: 79%)
Gene names: ARI, HPBE_LOCUS8140

Ligands and Environments

2 bound ligands:
Ligand EDO 2 x EDO
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: C2
Unit cell:
a: 149.779Å b: 35.755Å c: 61.289Å
α: 90° β: 92.07° γ: 90°
R-values:
R R work R free
0.184 0.18 0.23
Expression system: Homo sapiens

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