› 8q6q

X-ray diffraction
1.8Å resolution

Structure of human immunity related GTPase Q in complex with GABARAPL2.

Released:
DOI: 10.2210/pdb8q6q/pdb
PDB entry 8q6q coloured by chain, front view.
PDB entry 8q6q coloured by chain, side view.
PDB entry 8q6q coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Bailey HJ, Misra M, Pomirska J, Dikic I

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-250795 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Gamma-aminobutyric acid receptor-associated protein-like 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 117 amino acids
Theoretical weight: 13.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P60520 (Residues: 1-117; Coverage: 100%)
Gene names: FLC3A, GABARAPL2, GEF2
Sequence domains: Autophagy protein Atg8 ubiquitin like
Immunity-related GTPase family Q protein Chains: C, D
Molecule details ›
Chains: C, D
Length: 192 amino acids
Theoretical weight: 19.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WZA9 (Residues: 1-192; Coverage: 31%)
Gene names: FKSG27, IRGQ, IRGQ1

Ligands and Environments

1 bound ligand:
Ligand CIT 4 x CIT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P1
Unit cell:
a: 56.1Å b: 64.365Å c: 64.467Å
α: 60.56° β: 80.88° γ: 84.77°
R-values:
R R work R free
0.189 0.187 0.222
Expression system: Escherichia coli

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