› 8q7m

Electron Microscopy
3.26Å resolution

Tau - AD-MIA7 (tau intermediate amyloid)

Released:
DOI: 10.2210/pdb8q7m/pdb
PDB entry 8q7m coloured by chain, front view.
PDB entry 8q7m coloured by chain, side view.
PDB entry 8q7m coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Disease-specific tau filaments assemble via polymorphic intermediates.
Lövestam S, Li D, Wagstaff JL, Kotecha A, Kimanius D, McLaughlin SH, Murzin AG, Freund SMV, Goedert M, Scheres SHW
OpenAccess logo Nature (2023)
PMID: 38030728
Related structures: EMD-18224

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145405 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated protein tau Chains: A, B, C, D, E, F, G, H, I
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I
Length: 382 amino acids
Theoretical weight: 40 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10636 (Residues: 427-758; Coverage: 44%)
  • Best match: P10636-6 (Residues: 1-383)
Gene names: MAPT, MAPTL, MTBT1, TAU
Sequence domains: Tau and MAP protein, tubulin-binding repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.26Å
Relevant EMDB volumes: EMD-18224
Expression system: Escherichia coli

Quick links

Citations

3 citation in other articles

Cryo-EM structures of Aβ40 filaments from the leptomeninges of individuals with Alzheimer's disease and cerebral amyloid angiopathy.
Yang et al. (2023)
2 more