› 8q9s

X-ray diffraction
1.35Å resolution

STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 GENE PRODUCT) IN COMPLEX WITH THE INHIBITOR SGC-CK2-1

Released:
DOI: 10.2210/pdb8q9s/pdb
PDB entry 8q9s coloured by chain, front view.
PDB entry 8q9s coloured by chain, side view.
PDB entry 8q9s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery and Exploration of Protein Kinase CK2 Binding Sites Using CK2alpha Cys336Ser as an Exquisite Crystallographic Tool
Werner C, Lindenblatt D, Viht K, Uri A, Niefind K
Kinases Phosphatases (2023)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-539257 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha' Chain: A
Molecule details ›
Chain: A
Length: 364 amino acids
Theoretical weight: 42.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19784 (Residues: 1-350; Coverage: 100%)
Gene names: CK2A2, CSNK2A2
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
Ligand QBE 1 x QBE
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
Spacegroup: P1
Unit cell:
a: 46.217Å b: 47.682Å c: 50.562Å
α: 66.83° β: 89.43° γ: 88.93°
R-values:
R R work R free
0.137 0.135 0.169
Expression system: Escherichia coli

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