› 8qa0

Electron Microscopy
2.3Å resolution

Cryo-EM structure of Cx26 solubilised in LMNG - hemichannel classification - NConst conformation

Released:
DOI: 10.2210/pdb8qa0/pdb
PDB entry 8qa0 coloured by chain, front view.
PDB entry 8qa0 coloured by chain, side view.
PDB entry 8qa0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO2.
Brotherton DH, Nijjar S, Savva CG, Dale N, Cameron AD
OpenAccess logo Elife 13 (2024)
PMID: 38829031
Related structures: EMD-18291

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151332 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gap junction beta-2 protein Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 230 amino acids
Theoretical weight: 26.71 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P29033 (Residues: 1-226; Coverage: 100%)
Gene name: GJB2
Sequence domains: Connexin

Ligands and Environments

1 bound ligand:
Ligand PTY 24 x PTY
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.3Å
Relevant EMDB volumes: EMD-18291
Expression system: Spodoptera frugiperda

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