› 8qbn

Electron Microscopy
3.2Å resolution

Structure of the non-canonical CTLH E3 substrate receptor WDR26 bound to YPEL5

Released:
DOI: 10.2210/pdb8qbn/pdb
PDB entry 8qbn coloured by chain, front view.
PDB entry 8qbn coloured by chain, side view.
PDB entry 8qbn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism.
Gottemukkala KV, Chrustowicz J, Sherpa D, Sepic S, Vu DT, Karayel Ö, Papadopoulou EC, Gross A, Schorpp K, von Gronau S, Hadian K, Murray PJ, Mann M, Schulman BA, Alpi AF
Mol Cell 84 1948-1963.e11 (2024)
PMID: 38759627
Related structures: EMD-18316

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-244419 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
WD repeat-containing protein 26 Chains: 7, W
Molecule details ›
Chains: 7, W
Length: 645 amino acids
Theoretical weight: 70.54 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9H7D7 (Residues: 1-661; Coverage: 98%)
  • Best match: Q9H7D7-2 (Residues: 1-645)
Gene names: CDW2, MIP2, PRO0852, WDR26
Sequence domains:
Protein yippee-like 5 Chain: Y
Molecule details ›
Chain: Y
Length: 121 amino acids
Theoretical weight: 13.86 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P62699 (Residues: 1-121; Coverage: 100%)
Gene names: CGI-127, YPEL5
Sequence domains: Yippee zinc-binding/DNA-binding /Mis18, centromere assembly

Ligands and Environments

1 bound ligand:
Ligand ZN 3 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-18316
Expression system: Trichoplusia ni

Quick links