› 8qdn

Solution NMR

NMR2 Structure of KRAS G12V (GMPPNP bound) in complex with7-fluoro-N,N-dimethyl-1-benzofuran-2-carboxamide

Released:
DOI: 10.2210/pdb8qdn/pdb
PDB entry 8qdn coloured by chain, ensemble of 4 models, front view.
PDB entry 8qdn coloured by chain, ensemble of 4 models, side view.
PDB entry 8qdn coloured by chain, ensemble of 4 models, top view.
Source organism: Homo sapiens
Entry authors: Buetikofer M, Orts J

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-498650 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GTPase KRas Chain: A
Molecule details ›
Chain: A
Length: 169 amino acids
Theoretical weight: 19.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A7L2RV33 (Residues: 1-169; Coverage: 90%)
Gene names: Kras, NEOCOR_R02627
Sequence domains: Ras family

Ligands and Environments

1 bound ligand:
Ligand R60 1 x R60
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 1%
Refinement method: molecular dynamics
Expression system: Escherichia coli BL21(DE3)

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