› 8qdu

Solution NMR

Formation of left-handed helices by C2'-fluorinated nucleic acids under physiological salt conditions

Released:
DOI: 10.2210/pdb8qdu/pdb
PDB entry 8qdu coloured by chain, ensemble of 10 models, front view.
PDB entry 8qdu coloured by chain, ensemble of 10 models, side view.
PDB entry 8qdu coloured by chain, ensemble of 10 models, top view.
Source organism: synthetic construct
Primary publication:
Formation of left-handed helices by C2'-fluorinated nucleic acids under physiological salt conditions.
El-Khoury R, Cabrero C, Movilla S, Kaur H, Friedland D, Domínguez A, Thorpe JD, Roman M, Orozco M, González C, Damha MJ
Nucleic Acids Res (2024)
PMID: 38874502

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-246255 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*(FC)P*GP*(FC)P*GP*(FC)P*G)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 6 nucleotides
Theoretical weight: 1.86 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand CFL 6 x CFL

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 49%
Refinement method: molecular dynamics
Expression system: Not provided

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