› 8qi7

Electron Microscopy
2.9Å resolution

Cryo-EM Structure of Human Serine Hydroxymethyltransferase, isoform 2 (SHMT2)

Released:
DOI: 10.2210/pdb8qi7/pdb
PDB entry 8qi7 coloured by chain, front view.
PDB entry 8qi7 coloured by chain, side view.
PDB entry 8qi7 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Rutkiewicz M, Tran LH, Ruszkowski M
Related structures: EMD-18436

Function and Biology Details

Reaction catalysed: 
5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152742 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine hydroxymethyltransferase, mitochondrial Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 476 amino acids
Theoretical weight: 52.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P34897 (Residues: 29-504; Coverage: 94%)
Gene name: SHMT2
Sequence domains: Serine hydroxymethyltransferase

Ligands and Environments

No bound ligands
1 modified residue:
Ligand LLP 4 x LLP

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-18436
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

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