› 8qoj

Electron Microscopy
2.13Å resolution

human connexin-36 gap junction channel in complex with mefloquine

Released:
DOI: 10.2210/pdb8qoj/pdb
PDB entry 8qoj coloured by chain, front view.
PDB entry 8qoj coloured by chain, side view.
PDB entry 8qoj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of connexin-36 gap junction channel inhibition.
Ding X, Aureli S, Vaithia A, Lavriha P, Schuster D, Khanppnavar B, Li X, Blum TB, Picotti P, Gervasio FL, Korkhov VM
OpenAccess logo Cell Discov 10 68 (2024)
PMID: 38890333
Related structures: EMD-18540

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193853 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gap junction delta-2 protein Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 330 amino acids
Theoretical weight: 37.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UKL4 (Residues: 1-321; Coverage: 100%)
Gene names: GJA9, GJD2
Sequence domains: Connexin

Ligands and Environments

1 bound ligand:
Ligand YMZ 12 x YMZ
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.13Å
Relevant EMDB volumes: EMD-18540
Expression system: Homo sapiens

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