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Mycobacterium smegmatis inosine monophosphate dehydrogenase (IMPDH) ATP+ppGpp-bound form, super-compressed

Electron Microscopy
2.73Å resolution
PDB entry 8qqr coloured by chain, front view.
PDB entry 8qqr coloured by chain, side view.
PDB entry 8qqr coloured by chain, top view.
Source organism: Mycolicibacterium smegmatis MC2 155
Assembly composition:
homo octamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Inosine-5'-monophosphate dehydrogenase
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Multimeric state: homo octamer
Accessible surface area: 136735.57 Å2
Buried surface area: 63308.18 Å2
Dissociation area: 17,049.51 Å2
Dissociation energy (ΔGdiss): 253.48 kcal/mol
Dissociation entropy (TΔSdiss): 51.72 kcal/mol
Symmetry number: 8
PDBe Complex ID: PDB-CPX-269777

Macromolecules

Inosine-5'-monophosphate dehydrogenase
Chains: A, B, C, D, E, F, G, H
Length: 513 amino acids
Theoretical weight: 53.39 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0QSU3 (Residues: 1-513; Coverage: 100%)
Gene names: MSMEG_1602, guaB
Pfam:
Inosine-5'-monophosphate dehydrogenase in PDB entry 8qqr, assembly 1, front view.
Inosine-5'-monophosphate dehydrogenase in PDB entry 8qqr, assembly 1, side view.
Inosine-5'-monophosphate dehydrogenase in PDB entry 8qqr, assembly 1, top view.
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