› 8qqx

Electron Microscopy
3.01Å resolution

Mycobacterium smegmatis inosine monophosphate dehydrogenase (IMPDH) ATP+IMP-bound form, half-extended

Released:
DOI: 10.2210/pdb8qqx/pdb
PDB entry 8qqx coloured by chain, front view.
PDB entry 8qqx coloured by chain, side view.
PDB entry 8qqx coloured by chain, top view.
Source organism: Mycolicibacterium smegmatis MC2 155
Primary publication:
Deciphering the allosteric regulation of mycobacterial inosine-5'-monophosphate dehydrogenase.
Bulvas O, Knejzlík Z, Sýs J, Filimoněnko A, Čížková M, Clarová K, Rejman D, Kouba T, Pichová I
Nat Commun 15 6673 (2024)
PMID: 39107302
Related structures: EMD-18608

Function and Biology Details

Reaction catalysed: 
Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-249534 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inosine-5'-monophosphate dehydrogenase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 513 amino acids
Theoretical weight: 53.39 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0QSU3 (Residues: 1-513; Coverage: 100%)
Gene names: MSMEG_1602, guaB
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand IMP 8 x IMP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.01Å
Relevant EMDB volumes: EMD-18608
Expression system: Escherichia coli BL21(DE3)

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