› 8qud

Electron Microscopy
2.5Å resolution

Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT5

Released:
DOI: 10.2210/pdb8qud/pdb
PDB entry 8qud coloured by chain, front view.
PDB entry 8qud coloured by chain, side view.
PDB entry 8qud coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The binding and mechanism of a positive allosteric modulator of Kv3 channels.
Liang Q, Chi G, Cirqueira L, Zhi L, Marasco A, Pilati N, Gunthorpe MJ, Alvaro G, Large CH, Sauer DB, Treptow W, Covarrubias M
Nat Commun 15 2533 (2024)
PMID: 38514618
Related structures: EMD-18660

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155756 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Voltage-gated potassium channel KCNC1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 518 amino acids
Theoretical weight: 58.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P48547 (Residues: 1-511; Coverage: 100%)
Gene name: KCNC1
Sequence domains:

Ligands and Environments

5 bound ligands:
Ligand WY0 4 x WY0
Ligand ZN 4 x ZN
Ligand Y01 4 x Y01
Ligand PCF 4 x PCF
Ligand K 6 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.5Å
Relevant EMDB volumes: EMD-18660
Expression system: Homo sapiens

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