› 8qvn

Electron Microscopy
2.07Å resolution

Cryo-EM structure of Cx26 from Gallus Gallus in bicarbonate buffer

Released:
DOI: 10.2210/pdb8qvn/pdb
PDB entry 8qvn coloured by chain, front view.
PDB entry 8qvn coloured by chain, side view.
PDB entry 8qvn coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Multiple carbamylation events are required for differential modulation of Cx26 hemichannels and gap junctions by CO2.
Nijjar S, Brotherton D, Butler J, Dospinescu VM, Gannon HG, Linthwaite V, Cann M, Cameron A, Dale N
J Physiol (2025)
PMID: 39907096
Related structures: EMD-18670

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-286480 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gap junction protein Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 225 amino acids
Theoretical weight: 26.26 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: E1C2J9 (Residues: 1-225; Coverage: 100%)
Gene name: GJB2
Sequence domains: Connexin

Ligands and Environments

2 bound ligands:
Ligand LMT 24 x LMT
Ligand PTY 24 x PTY
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.07Å
Relevant EMDB volumes: EMD-18670
Expression system: Spodoptera frugiperda

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