› 8qwl

X-ray diffraction
1.65Å resolution

Structure of p53 cancer mutant Y163C

Released:
DOI: 10.2210/pdb8qwl/pdb
PDB entry 8qwl coloured by chain, front view.
PDB entry 8qwl coloured by chain, side view.
PDB entry 8qwl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators.
Balourdas DI, Markl AM, Krämer A, Settanni G, Joerger AC
Cell Death Dis 15 408 (2024)
PMID: 38862470

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138105 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cellular tumor antigen p53 Chain: A
Molecule details ›
Chain: A
Length: 219 amino acids
Theoretical weight: 24.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04637 (Residues: 94-312; Coverage: 56%)
Gene names: P53, TP53
Sequence domains: P53 DNA-binding domain

Ligands and Environments

3 bound ligands:
Ligand ZN 1 x ZN
Ligand EDO 3 x EDO
Ligand MLI 1 x MLI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2221
Unit cell:
a: 68.6Å b: 84.5Å c: 65.862Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.169 0.167 0.189
Expression system: Escherichia coli

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