› 8qxb

Electron Microscopy
3.86Å resolution

TDP-43 amyloid fibrils: Morphology-2

Released:
DOI: 10.2210/pdb8qxb/pdb
PDB entry 8qxb coloured by chain, front view.
PDB entry 8qxb coloured by chain, side view.
PDB entry 8qxb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM observation of the amyloid key structure of polymorphic TDP-43 amyloid fibrils.
Sharma K, Stockert F, Shenoy J, Berbon M, Abdul-Shukkoor MB, Habenstein B, Loquet A, Schmidt M, Fändrich M
Nat Commun 15 486 (2024)
PMID: 38212334
Related structures: EMD-18717

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo octadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-239155 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TAR DNA-binding protein 43 Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R
Length: 414 amino acids
Theoretical weight: 44.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13148 (Residues: 1-414; Coverage: 100%)
Gene names: TARDBP, TDP43
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.86Å
Relevant EMDB volumes: EMD-18717
Expression system: Escherichia coli

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