› 8qy6

Electron Microscopy
3.16Å resolution

Structure of interleukin 6 (gp130 P496L mutant).

Released:
DOI: 10.2210/pdb8qy6/pdb
PDB entry 8qy6 coloured by chain, front view.
PDB entry 8qy6 coloured by chain, side view.
PDB entry 8qy6 coloured by chain, top view.
Source organisms:
Entry authors: Gardner S, Bubeck D, Jin Y
Related structures: EMD-18743

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-240207 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Interleukin-6 receptor subunit beta Chains: A, D
Molecule details ›
Chains: A, D
Length: 917 amino acids
Theoretical weight: 102.57 KDa
Source organism: Mus musculus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q00560 (Residues: 1-917; Coverage: 100%)
Gene name: Il6st
Sequence domains:
Interleukin-6 Chains: B, E
Molecule details ›
Chains: B, E
Length: 212 amino acids
Theoretical weight: 23.74 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P05231 (Residues: 1-212; Coverage: 100%)
Gene names: IFNB2, IL6
Sequence domains: Interleukin-6/G-CSF/MGF family
Interleukin-6 receptor subunit alpha Chains: C, F
Molecule details ›
Chains: C, F
Length: 468 amino acids
Theoretical weight: 51.61 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P08887 (Residues: 1-468; Coverage: 100%)
Gene name: IL6R
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.16Å
Relevant EMDB volumes: EMD-18743
Expression system: Trichoplusia ni

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