Function and Biology Details
Reaction catalysed:
Cleavage of peptide bonds with very broad specificity.
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero heptadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-271556 (preferred)
Entry contents:
17 distinct polypeptide molecules
Macromolecules (17 distinct):
Proteasome subunit alpha type-2
Chain: A
Molecule details ›
Chain: A
Length: 234 amino acids
Theoretical weight: 25.93 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 234 amino acids
Theoretical weight: 25.93 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
P25787 (Residues: 1-234; Coverage: 100%)
Sequence domains:
Proteasome subunit alpha type-4
Chain: B
Molecule details ›
Chain: B
Length: 261 amino acids
Theoretical weight: 29.53 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 261 amino acids
Theoretical weight: 29.53 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
P25789 (Residues: 1-261; Coverage: 100%)
Sequence domains:
Proteasome subunit alpha type-7
Chain: C
Molecule details ›
Chain: C
Length: 248 amino acids
Theoretical weight: 27.93 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 248 amino acids
Theoretical weight: 27.93 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
O14818 (Residues: 1-248; Coverage: 100%)
Sequence domains:
Proteasome subunit alpha type-5
Chain: D
Molecule details ›
Chain: D
Length: 242 amino acids
Theoretical weight: 26.46 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 242 amino acids
Theoretical weight: 26.46 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
P28066 (Residues: 1-241; Coverage: 100%)
Sequence domains:
Proteasome subunit alpha type-1
Chain: E
Molecule details ›
Proteasome subunit alpha type-3
Chain: F
Molecule details ›
Chain: F
Length: 255 amino acids
Theoretical weight: 28.47 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 255 amino acids
Theoretical weight: 28.47 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
P25788 (Residues: 1-255; Coverage: 100%)
Sequence domains:
Proteasome subunit alpha type-6
Chain: G
Molecule details ›
Chain: G
Length: 246 amino acids
Theoretical weight: 27.43 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 246 amino acids
Theoretical weight: 27.43 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
P60900 (Residues: 1-246; Coverage: 100%)
Sequence domains:
Proteasome maturation protein
Chain: H
Molecule details ›
Chain: H
Length: 142 amino acids
Theoretical weight: 15.83 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Proteasome maturation factor UMP1
Length: 142 amino acids
Theoretical weight: 15.83 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q9Y244 (Residues: 1-141; Coverage: 100%)
Sequence domains: Proteasome maturation factor UMP1
Proteasome assembly chaperone 1
Chain: I
Molecule details ›
Chain: I
Length: 288 amino acids
Theoretical weight: 32.89 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Proteasome assembly chaperone 4
Length: 288 amino acids
Theoretical weight: 32.89 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
O95456 (Residues: 1-288; Coverage: 100%)
Sequence domains: Proteasome assembly chaperone 4
Proteasome assembly chaperone 2
Chain: J
Molecule details ›
Chain: J
Length: 265 amino acids
Theoretical weight: 29.45 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: PAC2 family
Length: 265 amino acids
Theoretical weight: 29.45 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q969U7 (Residues: 1-264; Coverage: 100%)
Sequence domains: PAC2 family
Proteasome subunit beta type-7
Chain: K
Molecule details ›
Chain: K
Length: 332 amino acids
Theoretical weight: 35.49 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 332 amino acids
Theoretical weight: 35.49 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q99436 (Residues: 1-277; Coverage: 100%)
Sequence domains:
Proteasome subunit beta type-3
Chain: L
Molecule details ›
Chain: L
Length: 205 amino acids
Theoretical weight: 22.97 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Proteasome subunit
Length: 205 amino acids
Theoretical weight: 22.97 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
P49720 (Residues: 1-205; Coverage: 100%)
Sequence domains: Proteasome subunit
Proteasome subunit beta type-2
Chain: M
Molecule details ›
Chain: M
Length: 202 amino acids
Theoretical weight: 22.89 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Proteasome subunit
Length: 202 amino acids
Theoretical weight: 22.89 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
P49721 (Residues: 1-201; Coverage: 100%)
Sequence domains: Proteasome subunit
Proteasome subunit beta type-5
Chain: N
Molecule details ›
Chain: N
Length: 264 amino acids
Theoretical weight: 28.54 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Proteasome subunit
Length: 264 amino acids
Theoretical weight: 28.54 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
P28074 (Residues: 1-263; Coverage: 100%)
Sequence domains: Proteasome subunit
Proteasome subunit beta type-1
Chain: O
Molecule details ›
Chain: O
Length: 241 amino acids
Theoretical weight: 26.52 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Proteasome subunit
Length: 241 amino acids
Theoretical weight: 26.52 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
P20618 (Residues: 1-241; Coverage: 100%)
Sequence domains: Proteasome subunit
Proteasome subunit beta type-4
Chain: P
Molecule details ›
Chain: P
Length: 264 amino acids
Theoretical weight: 29.22 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Proteasome subunit
Length: 264 amino acids
Theoretical weight: 29.22 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
P28070 (Residues: 1-264; Coverage: 100%)
Sequence domains: Proteasome subunit
Proteasome subunit beta type-6
Chain: Q
Molecule details ›
Chain: Q
Length: 239 amino acids
Theoretical weight: 25.34 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Proteasome subunit
Length: 239 amino acids
Theoretical weight: 25.34 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
P28072 (Residues: 1-239; Coverage: 100%)
Sequence domains: Proteasome subunit