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Dimeric ternary structure of E6AP-E6-p53

Source organisms:
Biochemical function: metal ion binding
Biological process: positive regulation of transcription by RNA polymerase II
Cellular component: nucleus

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EC 2.3.2.26: HECT-type E3 ubiquitin transferase

Reaction catalysed:
(1a) S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [HECT-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + S-ubiquitinyl-[HECT-type E3 ubiquitin transferase]-L-cysteine
Systematic name:
S-ubiquitinyl-[HECT-type E3-ubiquitin transferase]-L-cysteine:acceptor protein ubiquitin transferase (isopeptide bond-forming)
Alternative Name(s):
  • HECT E3 ligase
  • Ubiquitin transferase HECT-E3

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF07710
Domain description: P53 tetramerisation motif
Occurring in:
  1. Cellular tumor antigen p53
The deposited structure of PDB entry 8r1g contains 2 copies of Pfam domain PF07710 (P53 tetramerisation motif) in Cellular tumor antigen p53. Showing 1 copy in chain C (this domain is out of the observed residue ranges!).

PF00870
Domain description: P53 DNA-binding domain
Occurring in:
  1. Cellular tumor antigen p53
The deposited structure of PDB entry 8r1g contains 2 copies of Pfam domain PF00870 (P53 DNA-binding domain) in Cellular tumor antigen p53. Showing 1 copy in chain C.

PF18521
Domain description: Transactivation domain 2
Occurring in:
  1. Cellular tumor antigen p53
The deposited structure of PDB entry 8r1g contains 2 copies of Pfam domain PF18521 (Transactivation domain 2) in Cellular tumor antigen p53. Showing 1 copy in chain C (this domain is out of the observed residue ranges!).

PF08563
Domain description: P53 transactivation motif
Occurring in:
  1. Cellular tumor antigen p53
The deposited structure of PDB entry 8r1g contains 2 copies of Pfam domain PF08563 (P53 transactivation motif) in Cellular tumor antigen p53. Showing 1 copy in chain C (this domain is out of the observed residue ranges!).

PF00518
Domain description: Early Protein (E6)
Occurring in:
  1. Protein E6; Ubiquitin-like protein SMT3
The deposited structure of PDB entry 8r1g contains 2 copies of Pfam domain PF00518 (Early Protein (E6)) in Protein E6. Showing 1 copy in chain B.

PF00240
Domain description: Ubiquitin family
Occurring in:
  1. Protein E6; Ubiquitin-like protein SMT3
The deposited structure of PDB entry 8r1g contains 2 copies of Pfam domain PF00240 (Ubiquitin family) in Protein E6. Showing 1 copy in chain B (this domain is out of the observed residue ranges!).

PF00632
Domain description: HECT-domain (ubiquitin-transferase)
Occurring in:
  1. Ubiquitin-protein ligase E3A
The deposited structure of PDB entry 8r1g contains 2 copies of Pfam domain PF00632 (HECT-domain (ubiquitin-transferase)) in Ubiquitin-protein ligase E3A. Showing 1 copy in chain A.

PF16558
Domain description: Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
Occurring in:
  1. Ubiquitin-protein ligase E3A
The deposited structure of PDB entry 8r1g contains 2 copies of Pfam domain PF16558 (Amino-terminal Zinc-binding domain of ubiquitin ligase E3A) in Ubiquitin-protein ligase E3A. Showing 1 copy in chain A (this domain is out of the observed residue ranges!).

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