Function and Biology Details
Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-246217 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Acidic leucine-rich nuclear phosphoprotein 32 family member B
Molecule details ›
Chain: D
Length: 251 amino acids
Theoretical weight: 28.82 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Leucine Rich repeats (2 copies)
Length: 251 amino acids
Theoretical weight: 28.82 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
Q92688 (Residues: 1-251; Coverage: 100%)
Sequence domains: Leucine Rich repeats (2 copies)
Polymerase acidic protein
Molecule details ›
Chain: A
Length: 716 amino acids
Theoretical weight: 82.6 KDa
Source organism: Influenza A virus
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PA
Length: 716 amino acids
Theoretical weight: 82.6 KDa
Source organism: Influenza A virus
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: A5Z236 (Residues: 1-713; Coverage: 100%)
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PA
RNA-directed RNA polymerase catalytic subunit
Molecule details ›
Chain: B
Length: 757 amino acids
Theoretical weight: 86.62 KDa
Source organism: Influenza A virus
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PB1
Length: 757 amino acids
Theoretical weight: 86.62 KDa
Source organism: Influenza A virus
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: A5Z231 (Residues: 1-754; Coverage: 100%)
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PB1
Polymerase basic protein 2
Molecule details ›
Chain: C
Length: 898 amino acids
Theoretical weight: 101.38 KDa
Source organism: Influenza A virus
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 898 amino acids
Theoretical weight: 101.38 KDa
Source organism: Influenza A virus
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: A5Z230 (Residues: 1-752; Coverage: 100%)
Sequence domains:
- Influenza RNA polymerase PB2 N-terminal region
- Influenza RNA polymerase PB2 second domain
- Influenza RNA polymerase PB2 middle domain
- Influenza RNA polymerase PB2 helical domain
- Influenza RNA polymerase PB2 CAP binding domain
- Influenza RNA polymerase PB2 6th domain
- Influenza RNA polymerase PB2 C-terminal domain
