› 8r22

Electron Microscopy
3.9Å resolution

INTS9-INTS11-BRAT1-WDR73 complex

Released:
DOI: 10.2210/pdb8r22/pdb
PDB entry 8r22 coloured by chain, front view.
PDB entry 8r22 coloured by chain, side view.
PDB entry 8r22 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Assembly mechanism of Integrator's RNA cleavage module.
Sabath K, Qiu C, Jonas S
Mol Cell (2024)
PMID: 39032489
Related structures: EMD-18833

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-247775 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
BRCA1-associated ATM activator 1 Chain: A
Molecule details ›
Chain: A
Length: 827 amino acids
Theoretical weight: 88.77 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q6PJG6 (Residues: 1-821; Coverage: 100%)
Gene names: BAAT1, BRAT1, C7orf27
Sequence domains: HEAT repeat
Integrator complex subunit 9 Chain: B
Molecule details ›
Chain: B
Length: 658 amino acids
Theoretical weight: 73.89 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9NV88 (Residues: 1-658; Coverage: 100%)
Gene names: INTS9, RC74
Sequence domains:
Integrator complex subunit 11 Chain: C
Molecule details ›
Chain: C
Length: 612 amino acids
Theoretical weight: 69 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q5TA45 (Residues: 1-600; Coverage: 100%)
Gene names: CPSF3L, INTS11, RC68
Sequence domains:
WD repeat-containing protein 73 Chain: D
Molecule details ›
Chain: D
Length: 385 amino acids
Theoretical weight: 42.39 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q6P4I2 (Residues: 1-378; Coverage: 100%)
Gene names: HSPC264, WDR73

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-18833
Expression system: Trichoplusia ni

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