› 8r9a

X-ray diffraction
1.71Å resolution

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156239 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 7 Chain: A
Molecule details ›
Chain: A
Length: 371 amino acids
Theoretical weight: 42.24 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: P50613 (Residues: 1-346; Coverage: 100%)
Gene names: CAK, CAK1, CDK7, CDKN7, MO15, STK1
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
Ligand PEG 1 x PEG
Ligand I74 1 x I74
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21212
Unit cell:
a: 144.433Å b: 40.417Å c: 68.676Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.22 0.294
Expression system: Spodoptera

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