8rgh

Electron Microscopy
3.9Å resolution

Structure of dynein-2 intermediate chain DYNC2I1 (WDR60) in complex with the dynein-2 heavy chain DYNC2H1.

Released:

Function and Biology Details

Reaction catalysed:
DNA (containing 4-O-methylthymine) + protein L-cysteine = DNA (without 4-O-methylthymine) + protein S-methyl-L-cysteine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-273254 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Cytoplasmic dynein 2 intermediate chain 1 Chain: C
Molecule details ›
Chain: C
Length: 1066 amino acids
Theoretical weight: 122.87 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8WVS4 (Residues: 1-1066; Coverage: 100%)
Gene names: DYNC2I1, WDR60
Cytoplasmic dynein 2 intermediate chain 2 Chain: D
Molecule details ›
Chain: D
Length: 564 amino acids
Theoretical weight: 60.64 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q96EX3 (Residues: 1-536; Coverage: 100%)
Gene names: DYNC2I2, WDR34
Sequence domains: WD domain, G-beta repeat
Cytoplasmic dynein 2 light intermediate chain 1 Chain: E
Molecule details ›
Chain: E
Length: 351 amino acids
Theoretical weight: 39.68 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8TCX1 (Residues: 1-351; Coverage: 100%)
  • Best match: Q8TCX1-2 (Residues: 1-352)
Gene names: CGI-60, D2LIC, DYNC2LI1, LIC3
Sequence domains: Dynein light intermediate chain (DLIC)
Dynein light chain roadblock-type 1 Chains: G, H
Molecule details ›
Chains: G, H
Length: 96 amino acids
Theoretical weight: 10.93 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NP97 (Residues: 1-96; Coverage: 100%)
Gene names: BITH, DNCL2A, DNLC2A, DYNLRB1, HSPC162, ROBLD1
Sequence domains: Roadblock/LC7 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-19133
Expression system: Spodoptera frugiperda