› 8rgz

Electron Microscopy
3.27Å resolution

Trimeric HSV-1F gB ectodomain in postfusion conformation with three bound HDIT101 Fab molecules.

Released:
DOI: 10.2210/pdb8rgz/pdb
PDB entry 8rgz coloured by chain, front view.
PDB entry 8rgz coloured by chain, side view.
PDB entry 8rgz coloured by chain, top view.
Source organisms:
Primary publication:
Development of a highly effective combination monoclonal antibody therapy against Herpes simplex virus.
Seyfizadeh N, Kalbermatter D, Imhof T, Ries M, Müller C, Jenner L, Blumenschein E, Yendrzheyevskiy A, Grün F, Moog K, Eckert D, Engel R, Diebolder P, Chami M, Krauss J, Schaller T, Arndt M
OpenAccess logo J Biomed Sci 31 56 (2024)
PMID: 38807208
Related structures: EMD-19163

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-246022 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Envelope glycoprotein B Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 906 amino acids
Theoretical weight: 100.45 KDa
Source organism: Human alphaherpesvirus 1 strain F
Expression system: Homo sapiens
UniProt:
  • Canonical: P06436 (Residues: 1-5, 6-903; Coverage: 100%)
Gene names: UL27, gB
Sequence domains:
HDIT101 Fab heavy chain Chains: D, F, H
Molecule details ›
Chains: D, F, H
Length: 450 amino acids
Theoretical weight: 49.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
HDIT101 Fab light chain Chains: E, G, L
Molecule details ›
Chains: E, G, L
Length: 218 amino acids
Theoretical weight: 23.94 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.27Å
Relevant EMDB volumes: EMD-19163
Expression system: Homo sapiens

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