› 8rhg

Electron Microscopy
3.01Å resolution

CryoEM structure of human rho1 GABAA receptor in complex with GABA and pregnenolone sulfate

Released:
DOI: 10.2210/pdb8rhg/pdb
PDB entry 8rhg coloured by chain, front view.
PDB entry 8rhg coloured by chain, side view.
PDB entry 8rhg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Divergent mechanisms of steroid inhibition in the human rho1 GABAA receptor
Chen F, John C, Rebecca JH, Erik L
Nat Commun (2024)
Related structures: EMD-19175

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-227674 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gamma-aminobutyric acid receptor subunit rho-1 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 479 amino acids
Theoretical weight: 55.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P24046 (Residues: 1-479; Coverage: 100%)
Gene name: GABRR1
Sequence domains:

Ligands and Environments

6 bound ligands:
Ligand ABU 5 x ABU
Ligand NAG 10 x NAG
Ligand OCT 5 x OCT
Ligand A8W 1 x A8W
Ligand HEX 4 x HEX
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.01Å
Relevant EMDB volumes: EMD-19175
Expression system: Homo sapiens

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