› 8rhs

Solution NMR

Structure of the ZnF domain from human Roquin-1

Released:
DOI: 10.2210/pdb8rhs/pdb
PDB entry 8rhs coloured by chain, ensemble of 20 models, front view.
PDB entry 8rhs coloured by chain, ensemble of 20 models, side view.
PDB entry 8rhs coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure and RNA-binding of the helically extended Roquin CCCH-type zinc finger.
Tants JN, Oberstrass L, Weigand JE, Schlundt A
Nucleic Acids Res (2024)
PMID: 38953172

Function and Biology Details

Reaction catalysed: 
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178321 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Roquin-1 Chain: A
Molecule details ›
Chain: A
Length: 48 amino acids
Theoretical weight: 5.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: Q5TC82 (Residues: 411-454; Coverage: 4%)
Gene names: KIAA2025, RC3H1, RNF198

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 89%
Refinement method: simulated annealing
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

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