› 8rk2

Electron Microscopy
3.2Å resolution

Human Replication protein A (RPA; trimeric core) - ssDNA complex

Released:
DOI: 10.2210/pdb8rk2/pdb
PDB entry 8rk2 coloured by chain, front view.
PDB entry 8rk2 coloured by chain, side view.
PDB entry 8rk2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mechanism of single-stranded DNA annealing by RAD52-RPA complex.
Liang CC, Greenhough LA, Masino L, Maslen S, Bajrami I, Tuppi M, Skehel M, Taylor IA, West SC
OpenAccess logo Nature (2024)
PMID: 38658755
Related structures: EMD-19255

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-273246 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Replication protein A 70 kDa DNA-binding subunit Chain: A
Molecule details ›
Chain: A
Length: 616 amino acids
Theoretical weight: 68.21 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P27694 (Residues: 1-616; Coverage: 100%)
Gene names: REPA1, RPA1, RPA70
Sequence domains:
Replication protein A 32 kDa subunit Chain: B
Molecule details ›
Chain: B
Length: 270 amino acids
Theoretical weight: 29.28 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P15927 (Residues: 1-270; Coverage: 100%)
Gene names: REPA2, RPA2, RPA32, RPA34
Sequence domains: Replication protein A C terminal
Replication protein A 14 kDa subunit Chain: C

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-19255
Expression system: Spodoptera frugiperda

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