› 8rlt

X-ray diffraction
2.25Å resolution

TCR in complex with HLA-E*01:03 bound to HBV envelope 371-379 index peptide

Released:
DOI: 10.2210/pdb8rlt/pdb
PDB entry 8rlt coloured by chain, front view.
PDB entry 8rlt coloured by chain, side view.
PDB entry 8rlt coloured by chain, top view.
Source organisms:
Entry authors: Pengelly RJ, Godinho LF

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-275603 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Soluble HLA class I histocompatibility antigen, alpha chain E Chains: A, F
Molecule details ›
Chains: A, F
Length: 276 amino acids
Theoretical weight: 31.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13747 (Residues: 22-297; Coverage: 82%)
Gene names: HLA-6.2, HLA-E, HLAE
Sequence domains:
Beta-2-microglobulin Chains: B, G
Molecule details ›
Chains: B, G
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Large envelope protein Chains: C, H
Molecule details ›
Chains: C, H
Length: 9 amino acids
Theoretical weight: 1.01 KDa
Source organism: Hepatitis B virus
Expression system: Not provided
UniProt:
  • Canonical: Q67953 (Residues: 427-435; Coverage: 2%)
Gene name: S
T cell receptor alpha chain MC.7.G5; T cell receptor alpha variable 12-2 Chains: D, I
Molecule details ›
Chains: D, I
Length: 199 amino acids
Theoretical weight: 21.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DTU3 (Residues: 20-20, 115-123, 124-220; Coverage: 41%)
  • Canonical: A0A075B6T6 (Residues: 23-112; Coverage: 97%)
Gene names: TRA, TRAV12-2
Sequence domains:
T cell receptor beta chain MC.7.G5; T cell receptor beta variable 6-5 Chains: E, J
Molecule details ›
Chains: E, J
Length: 243 amino acids
Theoretical weight: 27.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DTU4 (Residues: 19-19, 113-266; Coverage: 50%)
  • Canonical: A0A0K0K1A5 (Residues: 20-112; Coverage: 98%)
Gene names: TRB, TRBV6-5
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P21
Unit cell:
a: 79.698Å b: 155.061Å c: 93.414Å
α: 90° β: 97.043° γ: 90°
R-values:
R R work R free
0.211 0.209 0.252
Expression systems:
  • Escherichia coli
  • Not provided

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