› 8rnu

Electron Microscopy
3.4Å resolution

CryoEM structure of recombinant human Bri2 BRICHOS oligomers

Released:
DOI: 10.2210/pdb8rnu/pdb
PDB entry 8rnu coloured by chain, front view.
PDB entry 8rnu coloured by chain, side view.
PDB entry 8rnu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis for different substrate-binding sites and chaperone functions of the BRICHOS domain.
Chen G, Wang Y, Zheng Z, Jiang W, Leppert A, Zhong X, Belorusova A, Siegal G, Jegerschöld C, Koeck PJB, Abelein A, Hebert H, Knight SD, Johansson J
Protein Sci 33 e5063 (2024)
PMID: 38864729
Related structures: EMD-19395

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-246106 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
BRI2 intracellular domain Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 119 amino acids
Theoretical weight: 13.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y287 (Residues: 113-231; Coverage: 45%)
Gene names: BRI, BRI2, ITM2B
Sequence domains: BRICHOS domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-19395
Expression system: Escherichia coli

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