› 8rq1

X-ray diffraction
3.11Å resolution

Crystal structure of CRBN-midi

Released:
DOI: 10.2210/pdb8rq1/pdb
PDB entry 8rq1 coloured by chain, front view.
PDB entry 8rq1 coloured by chain, side view.
PDB entry 8rq1 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kroupova A, Zollman D, Ciulli A

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-251817 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein cereblon Chain: A
Molecule details ›
Chain: A
Length: 329 amino acids
Theoretical weight: 37.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96SW2 (Residues: 41-187, 249-426; Coverage: 74%)
Gene names: AD-006, CRBN
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: C2221
Unit cell:
a: 52.031Å b: 96.405Å c: 148.086Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.268 0.267 0.3
Expression system: Escherichia coli

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