› 8rq4

Electron Microscopy
3.45Å resolution

Cryo-em structure of the rat Multidrug resistance-associated protein 2 (rMrp2) in complex with probenecid

Released:
DOI: 10.2210/pdb8rq4/pdb
PDB entry 8rq4 coloured by chain, front view.
PDB entry 8rq4 coloured by chain, side view.
PDB entry 8rq4 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural basis for the modulation of MRP2 activity by phosphorylation and drugs.
Mazza T, Roumeliotis TI, Garitta E, Drew D, Rashid ST, Indiveri C, Choudhary JS, Linton KJ, Beis K
OpenAccess logo Nat Commun 15 1983 (2024)
PMID: 38438394
Related structures: EMD-19433

Function and Biology Details

Reactions catalysed: 
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2)
ATP + H(2)O + glutathione-S-conjugate(Side 1) = ADP + phosphate + glutathione-S-conjugate(Side 2)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-274828 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-binding cassette sub-family C member 2 Chain: A
Molecule details ›
Chain: A
Length: 1541 amino acids
Theoretical weight: 173.57 KDa
Source organism: Rattus norvegicus
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q63120 (Residues: 1-1541; Coverage: 100%)
Gene names: Abcc2, Cmoat, Cmrp, Mrp2
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand Y01 1 x Y01
Ligand RTO 2 x RTO
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.45Å
Relevant EMDB volumes: EMD-19433
Expression system: Saccharomyces cerevisiae

Quick links

Citations

3 citation in other articles

Structural basis for autoinhibition by the dephosphorylated regulatory domain of Ycf1.
Khandelwal et al. (2024)
2 more