› 8rrg

X-ray diffraction
1.4Å resolution

Galectin-3 with a small molecule inhibitor

Released:
DOI: 10.2210/pdb8rrg/pdb
Model geometry
Fit model/data
PDB entry 8rrg coloured by chain, front view.
PDB entry 8rrg coloured by chain, side view.
PDB entry 8rrg coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Mac Sweeney A, Sager C

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148215 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Galectin-3 Chain: A
Molecule details ›
Chain: A
Length: 138 amino acids
Theoretical weight: 15.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P17931 (Residues: 113-250; Coverage: 55%)
Gene names: LGALS3, MAC2
Sequence domains: Galactoside-binding lectin

Ligands and Environments

3 bound ligands:
Ligand A1H2L 1 x A1H2L
Ligand SCN 1 x SCN
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P212121
Unit cell:
a: 34.55Å b: 57.57Å c: 62.19Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.188 0.208
Expression system: Escherichia coli

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